In diploids, sex affects genetic variation through two effects: segregation and recombination, which may in turn generate indirect selection for increased rates of sex. While selection for recombination has been explored for several decades, the benefits of segregation have been studied more recently. These sem from the fact that sex tends to bring populations closer to Hardy-Weinberg (HW) equilibrium. During this talk, I will present analytical and simulation results exploring the effect of different sources of depatures from HW equilibrium at loci subject to recurrent deleterious mutations: selection, finite population size (which tends to generate heterozygosity), and mitotic gene conversion/recombination (generating homozygosity). These results show that finite population size can have important effects, while gene conversion may have important effects if it occurs at a sufficiently high rate. Multilocus simulations allow to compare the strength of selection on sex due to segregation and recombination, and show that the effect of segregation is stronger in many cases. |